The comprehensive, on-line textbook of HIV disease from the University of California San Francisco and San Francisco General Hospital. Click to search by author or read more about the Knowledge Base.

Epidemiology of HIVEpidemiology of HIV in the United States
Dennis H. Osmond, PhD

Biology of HIV Infection and Treatment

Molecular Insights Into HIV Biology
Warner C. Greene, MD, PhD, and B. Matija Peterlin, MD

Structure, Expression, and Regulation of the HIV Genome
Thomas J. Hope, PhD, and Didier Trono, MD

Immunopathogenesis of HIV Infection
Michael M. Lederman, MD, Benigno Rodriguez, MD, MSc, and Scott Sieg, PhD

The Science of HIV Vaccine Development
R. Paul Johnson, MD, and Spyros Kalams, MD

Clinical Laboratory Methods

HIV Antibody Assays
Niel Constantine, PhD

Nucleic Acid-Based HIV-1 Viral Load Assays
Teri J. Liegler, PhD, and Robert M. Grant, MD, MPH

HIV Viral Antigen Assays
Niel Constantine, PhD

Assays for Antiretroviral Resistance
Robert W. Shafer, MD

Assays to Detect Host Immune Responses to HIV
Helen Horton, PhD, and M. Juliana McElrath, MD, PhD

Diagnosis and Clinical Management of HIV

 

Primary Care

Clinical Overview of HIV Disease
C. Bradley Hare, MD

How to Tell Patients They Have (or Do Not Have) HIV
Paul A. Volberding, MD

Epidemiology of Disease Progression in HIV
Dennis H. Osmond, PhD

Primary Care of Patients with HIV

Coping with the Psychological Stressors of HIV

Managing Medical Conditions Associated with Cardiac Risk in Patients with HIV
Daniel Wlodarczyk, MD

Symptom Management Guidelines
Lisa Capaldini, MD

Adverse Events Due to Non-Antiretroviral Medications During Treatment of HIV-Related Infections and Complications
Ian McNicholl, PharmD Christine Jamjian, PharmD

Immunizations in HIV Infection
Frederick M. Hecht, MD

Infection and Travel in Patients with HIV Disease
Janice K. Louie, MD, MPH, DTM&H Harry W. Lampiris, MD

Nutritional Issues in HIV

Diagnosis and Management of Primary (Acute) HIV Infection

Women and HIV
Meg D. Newman, MD

Primary Care of Infants and Children with HIV
Andrew T. Pavia, MD

Primary Care of Adolescents with HIV

Care of HIV Infection in the Developing World

Antiretroviral Therapy

Overview of Antiretroviral Drugs
Laurence Peiperl, MD, and Susa Coffey, MD

Initiating Antiretroviral Therapy
E.M. Kojic, MD, and Charles C.J. Carpenter, MD

Changing Antiretroviral Therapy: Why, When, and How
Timothy Wilkin MD, MPH, Marshall Glesby, MD, MPH, and Roy M. Gulick, MD, MPH

Clinical Implications of Immune Reconstitution in AIDS
Mark A. Jacobson, MD

Genotypic Testing for HIV-1 Drug Resistance
Robert W. Shafer, MD

Side Effects of Antiretroviral Drugs

Interactions of Antiretroviral Drugs

Metabolic Complications of HIV Therapy
Dominic C. Chow, MD, Larry J. Day, MD, Scott A. Souza, PharmD, and Cecilia M. Shikuma, MD

Adherence to HIV Antiretroviral Therapy
Edward L. Machtinger, MD, and David R. Bangsberg, MD

Treatment Interruption of Antiretroviral Therapy

Antiretroviral Treatment Monitoring in Developing Countries

Systems of Care

Critical Care of Patients with HIV
Kristina Crothers, MD, and Laurence Huang, MD

Surgery in Patients with HIV
William P. Schecter, MD, and Peter Stock, MD

Outpatient Administration of Intravenous Therapies in HIV Infection
Huey-Ling Lei, RN, MSN, Edward Lor, PharmD, Christine Schwartz, RD, Hopkins Stanley, RN, ACRN, and Mark Jacobson, MD

Inpatient Management of Adults with Advanced HIV Disease
Anne M. Hughes, RN, MN, FNP, and Diane Jones, RN

Care of Injection Drug Users
Steven L. Batki, MD, and James L. Sorensen, PhD

Substance Abuse and HIV

Community-Based Care in the Developing World

End of Life Care
Jeannee Parker Martin, RN, MPH

Clinical Manifestations of HIV

Dermatologic Manifestations of HIV
Toby A. Maurer, MD, and Timothy G. Berger, MD

Neurologic Manifestations of HIV
Dawn McGuire, MD

AIDS Dementia Complex
Richard W. Price, MD

HIV-Associated Psychiatric Disorders

Pulmonary Manifestations of HIV
Laurence Huang, MD

Cardiac Manifestations of HIV
Nina Rakhlin, MD, Priscilla Hsue, MD, and Melvin D. Cheitlin, MD

Endocrine Manifestations of HIV
Marc K. Hellerstein, MD

HIV-Associated Wasting
Kathleen Mulligan, PhD, and Morris Schambelan, MD

Hematologic Manifestations of HIV
Donald W. Northfelt, MD

Renal Manifestations of HIV
Rudolph A. Rodriguez, MD

Gastrointestinal Manifestations of HIV
Johannes Koch, MD, Lawrence S. Kim, MD, and Scott Friedman, MD

Ophthalmic Manifestations of HIV
Irma Ahmed, MD, Everett Ai, MD, Eugene Chang, MD, and Alan Luckie, MB, ChB

Otolaryngologic Manifestations of HIV
Kelvin C. Lee, MD, and Thomas A. Tami, MD

Oral Manifestations of HIV
Deborah Greenspan, DSC, BDS

Rheumatologic and Musculoskeletal Manifestations of HIV
Nancy Lane, MD

Radiographic Assessment of HIV-Associated Diseases
Philip C. Goodman, MD

Infections Associated with HIV

 

Bacterial Infections

Bacterial Infections Associated with HIV
Lisa Goozé, MD

Serious Bacterial Infections in Children with HIV
Shirley Jankelevich, MD

Pneumococcal Infection
Charles L. Daley, MD

Bartonella: Bacillary Angiomatosis and Peliosis
Jane E. Koehler, MD

Syphilis
Christopher S. Hall, MD, MS, and Gail Bolan, MD

Mycobacterium avium Complex and Atypical Mycobacterial Infections
Mark A. Jacobson, MD, and Judith A. Aberg, MD

Tuberculosis
Lisa Goozé, MD, and Charles L. Daley, MD

Fungal Infections

Pneumocystosis
Gifford S. Leoung, MD

Candidiasis
Carl J. Fichtenbaum, MD, and Judith A. Aberg, MD

Cryptococcosis
Judith A. Aberg, MD, and William G. Powderly, MD

Histoplasmosis
Erika M. Young, DO, and Mitchell Goldman, MD

Aspergillosis
Amy Sturt, MD, and Judith A. Aberg, MD

Coccidioidomycosis
Judith A. Aberg, MD

Paracoccidioidomycosis
Judith A. Aberg, MD

Penicilliosis
Woraphot Tantisiriwat, MD, and Judith A. Aberg, MD

Blastomycosis
Judith A. Aberg, MD

Viral Infections

Varicella-Zoster Virus
Kim S. Erlich, MD, and Sharon Safrin, MD

Herpes Simplex Virus
Kim S. Erlich, MD

Cytomegalovirus
W. Lawrence Drew, MD, PhD, and Jacob P. Lalezari, MD

Viral Hepatitis
Mandana Khalili, MD

Parasitic Infections

Cryptosporidiosis, Cyclosporiasis, and Isosporiasis
Carolyn Petersen, MD

Microsporidiosis
Carolyn Petersen, MD

Toxoplasmosis
Carlos S. Subauste, MD

Malaria
James Whitworth, MD, FRCP

Malignancies Associated with HIV

 

Kaposi Sarcoma and Human Herpesvirus 8

Human Herpesvirus-8, Kaposi Sarcoma, and AIDS-Associated Neoplasms
Corey Casper, MD, MPH

Clinical Characteristics of Kaposi Sarcoma
Susan E. Krown, MD

Treatment of HIV-Associated Kaposi Sarcoma
Jamie H. Von Roenn, MD

Lymphoma

Pathogenesis of HIV-Associated Lymphoma
Valerie L. Ng, MD, PhD, and Michael S. McGrath, MD, PhD

Clinical Presentation and Management of HIV-Associated Lymphoma
Lawrence D. Kaplan, MD

Human Papilloma Virus-Associated Neoplasms

Clinical Management of Lower Genital Tract Neoplasia among Women with HIV
Priscilla Abercrombie, RN, NP, PhD

Anogenital Neoplasia
J. Michael Berry, MD, and Joel M. Palefsky, MD

Other Malignancies

Other Malignancies Associated with HIV
Donald W. Northfelt, MD

Transmission and Prevention of HIV

 

Concepts and Techniques of HIV Prevention

Effective Behavioral Interventions

Voluntary Counseling and Testing

Theory and Practice of Client-Centered Counseling and Testing
Nicolas Sheon, PhD

Modes of Transmission and Interventions

Sexual Transmission of HIV

Safer Sex Methods
Tim Lane, PhD, MPH, and Herminia Palacio, MD, MPH

Preventing Mother-to-Child Transmission

Microbicides and Female Controlled Prevention Technologies

Prophylaxis Following Occupational Exposure to HIV

Prophylaxis Following Nonoccupational Exposure to HIV

Transmission of HIV by Blood, Blood Products, Tissue Transplantation, and Artificial Insemination
Elizabeth Donegan, MD

HIV Vaccines

The Science of HIV Vaccine Development
R. Paul Johnson, MD, and Spyros Kalams, MD

Policy Issues in AIDS Vaccine Development
Chris Collins, MPP

HIV Transmission and Prevention in Specific Populations

Epidemiology and HIV Transmission in Injection Drug Users
Jeffrey H. Burack, MD, MPP, BPhil, and David Bangsberg, MD, MPH

HIV Prevention in Injection Drug Users
David R. Gibson, PhD

HIV Transmission and Prevention in Adolescents
Douglas Kirby, PhD

HIV Transmission and Prevention in Gay Men

Systematic Review of HIV Behavioral Prevention Research in African Americans
Lynae A. Darbes, PhD, Gail E. Kennedy, MPH, Greet Peersman, PhD, Lev Zohrabyan, MD, MPH, and George W. Rutherford, MD

Systematic Review of HIV Behavioral Prevention Research in Asian Americans and Pacific Islanders
Lynae A. Darbes, PhD, Gail E. Kennedy, MPH, Greet Peersman, PhD, Lev Zohrabyan, MD, MPH, and George W. Rutherford, MD

Systematic Review of HIV Behavioral Prevention Research in Latinos
Lynae A. Darbes, PhD, Gail E. Kennedy, MPH, Greet Peersman, PhD, Lev Zohrabyan, MD, MPH, and George W. Rutherford, MD

HIV Transmission and Prevention in Native Americans

HIV Transmission and Prevention in Prisons
Elizabeth Kantor, MD

HIV Transmission and Prevention in Transgender People

Integrating HIV Prevention into the Care of People with HIV
Grant Colfax, MD, and Carol Dawson-Rose, RN, PhD

HIV Policy

 

Global

Resource Allocation

Treatment Access

Socioeconomic Impact of HIV/AIDS

Ethical Dimensions
Leslie E. Wolf, JD, MPH, and Bernard Lo, MD

Cost-Effectiveness of HIV Prevention in Developing Countries
Elliot Marseille, DrPH, MPP, Stephen F. Morin, PhD, Chris Collins, MPP, Todd Summers, Thomas J. Coates, PhD, and James G. Kahn, MD, MPH

Human Rights
Sofia Gruskin, JD, MIA, and Daniel Tarantola, MD

Forced Migration and Transmission of HIV and Other Sexually Transmitted Infections: Policy and Programmatic Responses
Therese McGinn, MPH, Susan J. Purdin, MPH, RN, Sandra Krause, MPH, BSN, and Rachel K. Jones, MA

Sexual Violence

Orphans & Affected Families

Policy Issues in AIDS Vaccine Development
Chris Collins, MPP

HIV/AIDS and the Workplace

Debt Relief and Poverty

Food Security and HIV/AIDS

The Stigma of HIV Infection

United States

Government & Nongovernmental Responses
Todd Summers

HIV/AIDS Surveillance and Reporting in the United States
Chris Collins, MPP

Health Care Financing